Expierience with
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Areas of Interest

Every day I learn from the many amazing people with whom I get to work and collaborate across a range of my professional interests, which include:

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Genetics

My first passions are genetics and molecular pathology. I previously worked at the Hospital for Sick Children doing research on brain cancer.

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Software

At PhenoTips, I'm working on the world's first Genomic Health Record for clinical phenotyping in medical genetics and rare disease research.

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Lean Six Sigma

Combining my knowledge of medicine & technology, I providing consulting related to the technical & strategic aspects in the healthcare, research & biotech industries.

My Education & Experience

I hold a BSc in Chemistry and Biology from Ryerson University, a PhD in Laboratory Medicine & Pathobiology from the University of Toronto and certification in Lean Six Sigma. My previous experience includes an eight and a half year stint as a medical research scientist at the Hospital for Sick Children, where I worked with teams of clinicians and researchers from all over the world on projects in oncology, cancer genetics, rheumatology and molecular pathology.

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Research Contributions

My contributions to the medical community included the discovery of novel mutations in human cancer and the development of clinical correlates based on which a new World Health Organization classification was implemented in 2016 for paediatric gliomas (diffuse midline glioma, H3 K27M–mutant), a type of childhood brain cancer. I also have experience in the biopharmaceutical industry having worked for a company which produced disease antigens from infectious pathogens for medical diagnostic and vaccine research, among other biopharmaceuticals.

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Peer Reviewed Publications

  • Identification of complex genomic rearrangements in cancer using CouGAR. Genome Research 2017 27(1):107-117    [PDF - 5.02MB]
  • Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations. Nature Genetics 2014 46(5);451-56    [PDF - 840KB]
  • Pathology, molecular genetics, and epigenetics of diffuse intrinsic pontine gliomas.
    Frontiers in Oncology 2015 30;5:147    [PDF - 1.67MB]
  • Histopathological spectrum of paediatric diffuse intrinsic pontine glioma: diagnostic and therapeutic implications. Acta Neuropathologica 2014 128(4)573-81    [PDF - 1.26MB]
  • 27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. Acta Neuropathologica 2012 124(3)439-47    [PDF - 461KB]
  • SEE ALL ON PUBMED
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My WHY

This video will hopefully shed some light on why I do what I do. I spoke at a TechTO/HealthTO event in Toronto about "Alphabɘt Soup: Deep Phenotyping of Rare, Ultra-Rare and Undiagnosed Diseases"

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Podcasts & Webinars

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Podcast and radio show on WHUS 97.1FM discussing genetics, rare diseases, cancer, pathology and how those relate to the vision at Gene42 (currently named PhenoTips).

DNA Today - Episode #78

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I speak with Dr. Peter Robinson, founder of the groundbreaking Human Phenotype Ontology, about the importance of deep phenotpying in precision medidicne.

PhenoTips Speaker Series - Episode #3

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Dr. John McDermott from Manchester Centre for Genomic Medicine joined me to discuss ways in which genomics can be integrated into routine clinical care.

PhenoTips Speaker Series - Episode #9

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Professor of Computational Genomics, Dr. Damian Smedley, developer of Exomiser discusses the role of phenotyping in improving diagnostic outcomes.

PhenoTips Speaker Series - Episode #10

Contact Information

  • Don't hesitate to send me a message through the contact form below
  • Greater Toronto Area, Ontario, Canada